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Evaluates the efficacy of a variety benzodiazepines, including diazepam, with regard to the treatment of alcohol and drug dependence.
Citation: Kochen, M., Hahn, H., and Kuchen, S. (2011) Pharmacology Pharmacotherapy of D-Amphetamine and D-Alprazolam. PLoS ONE 6(6): e21770. doi:10.1371/journal.pone.0021770
Diazepam for Sale.com
Evaluate the efficacy of a variety benzodiazepines, including diazepam, with regard to the treatment of alcohol and drug dependence.
Erowid Chemical Identification: benzodiazepines
Diazepam and diazepam-related compounds are commonly abused as anxiolytic medications, with a range of side effects.
Diazepam and its metabolite alprazolam are known for their abuse potential and effects on GABA receptors. Although not well studied, the efficacy of diazepam at blocking the effects of alcohol can be limited by the induction of tolerance, withdrawal symptoms, and the development of tolerance to other drugs. The development of dependence on diazepam is known in animals, suggesting that the drug may be an important risk factor for developing alcoholism.
The following table summarizes pharmacological effects of diazepam and metabolites (alprazolam Ambien in ireland diazepam) in animals. Diazepam is the principal substance that inhibits binding of GABA receptors in brain. Diazepam and other compounds of this class have been shown to significant effects on the GABA binding properties of brain tissue, thus influencing various aspects of behavior.
Diazepam and diazepam-related compounds have been shown to significant side effects including sedation and respiratory depression, but little attention has been given to their abuse potential.
Erowid Chemistry: Diazepam
Citation: Kochen, M., Hahn, H., and Kuchen, S. (2010) Pharmacology Pharmacotherapy of D-Alprazolam. PLoS ONE 5(12): e15197. doi:10.1371/journal.pone.0015197
Citation: Kochen, M., Hahn, H., and Kuchen, S. (2008) Pharmacology Pharmacotherapy of Aripiprazole. PLoS ONE 3(11): e3363. doi:10.1371/journal.pone.0003363
Erowid Chem. Rep. 2009 Feb;12(2):2-3. Effects of diazepam on GABA-mediated synaptic transmission in the hippocampal CA1 subfields as measured by doublecortin mRNA in cultured cortical slices. [Article.PDF]
Drug Effects on Brain Function
Diazepam and benzodiazepine drugs are among the commonest class of prescription medications for treatment alcohol and drug dependence worldwide. D-Amphetamine is an abused depressant that metabolized by a metabolizing system, the monoamine oxidase system. These systems metabolize many medications, including opioids and amphetamines.
In a clinical study of diazepam, the efficacy diazepam Ambien 5mg 180 $395.00 $2.19 as adjunctive treatment in an alcoholic patient who was unresponsive to treatment with standard pharmacological pharmacotherapies was demonstrated. The results of this study demonstrate the therapeutic potential of diazepam as adjunctive therapy in patients who failed pharmacotherapy alone. Although more research is needed, diazepam appears to be an effective treatment for alcohol use disorders.
Diazepam Dosage for Alcoholism/Drug Dependence
Tolerance to diazepam is associated with prolonged exposure to it and has been recommended that long-term administration of diazepam be avoided to avoid excessive tolerance its actions in the CNS.
Diazepam Interactions with Other Drugs
Alprazolam is metabolized by the GABA-Aα and GABA-Aβ systems is therefore also a GABA-A agonist. Alprazolam is commonly used with diazepam to treat alcohol and drug dependence. Diazepam
Diazepam is metabolized by the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMP) system. AMP is a GABA-A agonist, so diazepam is thought to compete with diazepam for AMPA receptors in the amygdala, leading to a decrease in the effect of diazep.
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